antimitotic drugs

antimitotic drugs
Drugs that block mitosis; the term is often used of those which cause metaphase-arrest such as colchicine and the vinca alkaloids. Many anti-tumour drugs are antimitotic, blocking proliferation rather than being cytotoxic.

Dictionary of molecular biology. 2004.

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  • antimitotic — ¦anˌtī, ¦antē, ¦antə̇ˌ adjective ( s) Etymology: anti (I) + mitotic : inhibiting or disrupting mitosis antimitotic drugs antimitotic activity • antimitotic noun …   Useful english dictionary

  • antimitotic — 1. Having an arresting action upon mitosis. 2. A drug having such an effect; e.g., a folic acid antagonist that is used in leukemia to inhibit the multiplication of white cells. * * * an·ti·mi·tot·ic .ant i mī tät ik, .an .tī …   Medical dictionary

  • antimitotic — n. any one of a group of drugs that inhibit cell division and growth, e.g. doxorubicin. The drugs used to treat cancer are mainly antimitotics. See also: antimetabolite, cytotoxic drug …   The new mediacal dictionary

  • antimitotic — /an tee muy tot ik, mi , an tuy /, Biochem., Pharm. adj. 1. of or pertaining to certain substances capable of arresting the process of cell division. n. 2. any such substance, as certain drugs used to destroy cancer cells. [1965 70; ANTI +… …   Universalium

  • Discovery and development of tubulin inhibitors — Tubulin inhibitors interfere directly with the tubulin system which is in contrast to those drugs acting on DNA for cancer chemotherapy. Microtubules play an important role in eukaryotic cells. Alpha and beta tubulin, the main components of… …   Wikipedia

  • Aurora inhibitors — Aurora kinases regulate cell cycle transit from G2 through cytokinesis and, thus, are targets in cancer therapy [Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras come into view. Current Opin in Cell Biol.(2003) 15:… …   Wikipedia

  • vinca alkaloid — n any of several alkaloids (as vinblastine and vincristine) obtained esp. from the rosy periwinkle * * * one of a group of antimitotic drugs (see cytotoxic drug) derived from the periwinkle (Vinca rosea). Vinca alkaloids, which are usually… …   Medical dictionary

  • vinca alkaloid — one of a group of antimitotic drugs (see also cytotoxic drug) derived from the periwinkle (Vinca rosea). Vinca alkaloids are used especially to treat leukaemias and lymphomas; they include vinblastine (Velbe), vincristine (Oncovin), and vindesine …   The new mediacal dictionary

  • History of cancer chemotherapy — The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. Cancer drug development has exploded since then into a multi billion dollar industry. The targeted therapy revolution has… …   Wikipedia

  • rhizoxin — A substance that is being studied in the treatment of cancer. It comes from a fungus and is similar to vinca alkaloid drugs. It belongs to the family of drugs called antimitotic agents …   English dictionary of cancer terms

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